27Apr, 2019

The Receptor of Progesterone

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-Definition: The progesterone receptor (PR), also known as NR3C3, is a protein found inside cells. It is activated by the steroid hormone progesterone. In humans, PR is encoded by a single PGR gene residing on chromosome 11 has two isoforms, PR-A and PR-B, which differ in their molecular weight, PR-B is the positive regulator of the effects of progesterone, while PR-A serves to antagonize the effects of PR-B. Progesterone is necessary to induce progesterone receptors. When there is no binding hormone, the carboxyl terminal inhibits transcription. Binding to a hormone […]
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27Apr, 2019

Antiandrogens and their Importance

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-Definition: An antiandrogen or androgenic antagonist is a group of drugs that exert an antagonistic action or hormonal suppression capable of preventing or inhibiting the biological effects of androgens or male sex hormones on the normal responses of body tissues to these hormones. Antiandrogens normally act by blocking androgen receptors, competing with binding sites on the surface of cells, nullifying the function of androgens, except in those cases that inhibit the conversion of testosterone to dihydrotestosterone, which is more potent than dihydrotestosterone and therefore are partially antiandrogenics. -Various Uses: Antiandrogens […]
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