27Oct, 2019

Isolated LH Deficiency

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-Summary: LH is not necessary for the differentiation of the genitals in the male sense. In fact, in our species, HCG (human chorionic gonadotropin) produced by the placenta, very homologous to LH, will allow the masculinization of the genital organs before birth by acting on the same LHR receptor. However, after birth, LH is essential for testicular maturation, especially for the proliferation and maturation of Leydig cells, which will acquire the ability to secrete testosterone, allowing pubertal virilization and activation of spermatogenesis. -Development: About 15% of couples are infertile and […]
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27Oct, 2019

Importance of OH-progesterone

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-Summary: 17-hydroxy-progesterone (17α-OH-P) is a steroid produced in the adrenal glands and gonads (testicles or ovaries). It is a natural progestogen, and is increased during the third trimester of pregnancy mainly due to fetal adrenal production. As a hormone, 17OHP also interacts with progesterone receptors. -Development: Normal levels in children are 3-90 ng/dl, in men: 139 ng/dL (< 4.17 nmol/L) and in women: it depends on the stage of the ovarian cycle: Follicular phase: 0.2 – 2.6 ng/ml Luteal phase: 0.35 – 4.0 ng/dL Postmenopause: 0.1-1.2 ng/ml Congenital adrenal hyperplasia […]
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27Oct, 2019

Estradiol and Male Reproductive Function

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-Summary: Traditionally, testosterone and estrogen have been considered male and female sex hormones, respectively. However, estradiol, the predominant form of estrogen, also plays a role in male sexual function. Estradiol in men is essential for libido modulation, erectile function, and spermatogenesis. -Development: Estrogen receptors, as well as aromatase, the enzyme that converts testosterone into estrogen, are abundant in the brain, penis and testicles, organs important for sexual function. In the brain, estradiol synthesis increases in areas related to sexual arousal. In addition, in the penis, estrogen receptors are found throughout […]
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