27Apr, 2019

The Receptor of Progesterone

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-Definition: The progesterone receptor (PR), also known as NR3C3, is a protein found inside cells. It is activated by the steroid hormone progesterone. In humans, PR is encoded by a single PGR gene residing on chromosome 11 has two isoforms, PR-A and PR-B, which differ in their molecular weight, PR-B is the positive regulator of the effects of progesterone, while PR-A serves to antagonize the effects of PR-B. Progesterone is necessary to induce progesterone receptors. When there is no binding hormone, the carboxyl terminal inhibits transcription. Binding to a hormone […]
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27Apr, 2019

Antiandrogens and their Importance

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-Definition: An antiandrogen or androgenic antagonist is a group of drugs that exert an antagonistic action or hormonal suppression capable of preventing or inhibiting the biological effects of androgens or male sex hormones on the normal responses of body tissues to these hormones. Antiandrogens normally act by blocking androgen receptors, competing with binding sites on the surface of cells, nullifying the function of androgens, except in those cases that inhibit the conversion of testosterone to dihydrotestosterone, which is more potent than dihydrotestosterone and therefore are partially antiandrogenics. -Various Uses: Antiandrogens […]
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27Apr, 2019

El Receptor de Progesterona

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-definición: El receptor de progesterona (PR), también conocido como NR3C3, es una proteína que se encuentra dentro de las células. Es activado por la hormona esteroide progesterona. En los humanos, la PR está codificada por un único gen PGR que reside en el cromosoma 11 y tiene dos isoformas, PR-A y PR-B, que difieren en su peso molecular, PR-B es el regulador positivo de los efectos de la progesterona, mientras que PR-A sirve para antagonizar los efectos de PR-B. La progesterona es necesaria para inducir los receptores de progesterona. Cuando […]
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