DHEA is a steroid hormone, is an acronym for Dehydroepiandrosterone or Androstenolone, and one of the most important produced by the human body, especially in the adrenal glands, being the precursor of many other hormones, and is a prohormone, among the most abundant in the body.
It is also produced in small quantities by the ovaries, testicles and brain. Steroids are a large family of compounds with a common basic structure that have anti-inflammatory, sex-determining, and growth-regulating functions.
IT is pregnenolone the major precursor, as it is the source of almost all other steroid hormones, including DHEA, progesterone, testosterone, estrogens, and cortisol. The role of DHEA in the human body is important, as it has the ability to create hormonal balance and thus maintain the basic functions of the body.
Dehydroepiandrosterone sulfate (DHEA-S) is a steroid hormone produced mainly in the cortex of the adrenal glands (the outer part of the two adrenal glands, which are located above the kidneys). Although it is a weak androgen (a male sex hormone), it is produced by both men and women.
DHEA has been found to act directly on several neurotransmitters, influencing them as a positive modulator of the NMDA receptor, (i.e. one of the receptors of the exitatory neurotransmitter glutamate, the most abundant in the nervous system, involved in the proper functioning of the brain for learning or memory) and as a negative modulator of the more abundant inhibitory receptor called GABA.
DHEA can be measured in a simple blood test as reported in DHEAS (sulfate S). The normal range of DHEA is 0.95 – 11.6 umol/L in women and 2.20- 15.2 umol/L in men, depending on the laboratory.
DHEA is transformed into testosterone in the ovaries, adrenal glands, adipose tissue, bones, muscles, breasts, skin and liver. In addition to becoming testosterone and estradiol can be transformed into androstenediol, an androgen with much activity. DHEA sulfate is mainly synthesized in the adrenal glands and can pass back to DHEA by peripheral conversion.
During pregnancy, DHEA-S and its hydroxylated metabolites are secreted by the fetal adrenal gland in large amounts. Within weeks after birth, DHEA-S levels drop by 80% or more and remain low until the onset of adrenarche, around age 7, when they rise again.
Our organism produces small quantities of this hormone again at the age of 7 years, and it is what is called adrenarquia, until the age of 25 when it reaches its maximum level and then decrease its production by 20% every ten years.
The relationship between DHEA and DHEA-sulphate is that both hormones are united by albumin, but the union of DHEA-S is much closer. In the gonads and various other tissues, especially in the skin, steroid sulfatases can convert DHEA-S back into DHEA, which can then be metabolized into more potent androgens and estrogens.
Early adrenarche is not associated with precocious puberty or any reduction in final stature or overt androgenization and is generally considered a benign, non-interventional condition.
However, girls with early adrenarche may be at risk for polycystic ovary syndrome in adulthood, and some boys may develop early penis enlargement.
-Uses in clinical practice:
DHEA dehydroepiandrosterone is used by men for erectile dysfunction (ED) and by healthy or menopausal women, or with hormonal problems and to improve well-being and sexuality.
There are also patients with systemic lupus erythematosus (LSE) using DHEA have noted improvement. It seems to have very beneficial effects in cases of osteoporosis, multiple sclerosis (MS), Addison’s disease, depression, schizophrenia, chronic fatigue syndrome (CFS), to delay the symptoms of Parkinson’s disease, among others.
Glucocorticoid and mineralocorticoid deficiencies in Addison’s disease (adrenal insufficiency) require a lifetime hormone replacement, but the associated failure of DHEA synthesis is not corrected, so DHEA supplementation improves fatigue and mood along with overall well-being in both sexes.
DHEA is used successfully in weight loss and to stimulate the immune system. People with HIV use DHEA to relieve fatigue and depression.
Women who have gone through menopause and suffer from vaginal atrophy as well as induced increased sexual interest and improved vaginal dryness.
To avoid the risks of osteoporosis: among healthy older adults, daily administration of 50 mg DHEA has a modest and selective beneficial effect on BMD (bone mineral density) and bone resorption in women, but does not provide bone benefits for men.
In the USA, it is available free of charge in tablets of 5, 10, 25 and 50 mg. However, in some countries a prescription is required and in others only by means of a prescribed master formula.
Glutamic Acid 500mg
viatamine E 200mg
Prepare 3 vials with 30 doses: dosage 1 daily, in some cases 5 or 10 mg is enough.
DHEA is contraindicated in patients with a history of breast, uterine or prostate cancer.