27Apr, 2019

The Receptor of Progesterone

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-Definition: The progesterone receptor (PR), also known as NR3C3, is a protein found inside cells. It is activated by the steroid hormone progesterone. In humans, PR is encoded by a single PGR gene residing on chromosome 11 has two isoforms, PR-A and PR-B, which differ in their molecular weight, PR-B is the positive regulator of the effects of progesterone, while PR-A serves to antagonize the effects of PR-B. Progesterone is necessary to induce progesterone receptors. When there is no binding hormone, the carboxyl terminal inhibits transcription. Binding to a hormone […]